Endocrine Abstracts

Introduction: The involvement of the Wnt/ß-catenin pathway is apparent different epithelial human cancers. Wnt stabilizes ß-catenin (free ß-catenin) by preventing its phosphorylation which targets ß-catenin for degradation. Free ß-catenin is translocated to the nucleus where it stimulates a number of genes that modulate proliferation and differentiation upon binding to TCF/LEF-1. We have previously shown that Wnt/ß-catenin pathway is dysregulated ...